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Target
Leukotriene B4 receptor 1
Ligand
BDBM406387
Substrate
n/a
Meas. Tech.
BLT-1 cAMP Assay
EC50
556±n/a nM
Citation
 Han, Y; Lim, J; Tummanapalli, S; Siliphaivanh, P; Spencer, K Aryl acylsulfonamides as BLT1 antagonists US Patent  US10336733 Publication Date 7/2/2019 
Target
Name:
Leukotriene B4 receptor 1
Synonyms:
BLT | BLT1 | BLTR | CMKRL1 | Chemoattractant receptor-like 1 | G-protein coupled receptor 16 | GPR16 | LT4R1_HUMAN | LTB4-R 1 | LTB4R | Leukotriene B4 R1 | Leukotriene B4 receptor | Leukotriene B4 receptor 1 | P2RY7 | P2Y purinoceptor 7 | P2Y7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37582.68
Organism:
Homo sapiens (Human)
Description:
Q15722
Residue:
352
Sequence:
MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
  
Inhibitor
Name:
BDBM406387
Synonyms:
N-(tert-Butylsulfonyl)-2-((rac-trans)-4-hydroxy-3-((5-methyl-1,3,4-thiadiazol-2-yl)methyl)chroman-7-yl)benzamide | US10336733, Example 31
Type:
Small organic molecule
Emp. Form.:
C24H27N3O5S2
Mol. Mass.:
501.618
SMILES:
Cc1nnc(C[C@H]2COc3cc(ccc3[C@@H]2O)-c2ccccc2C(=O)NS(=O)(=O)C(C)(C)C)s1 |r|
Structure:
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