Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM118725
Substrate
n/a
Meas. Tech.
Receptor Radioligand Binding Assay
Temperature
298.15±n/a K
Ki
10.00±n/a nM
Comments
extracted
Citation
 Letavic, MA; Rudolph, DA; Savall, BM; Shireman, BT; Swanson, D Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators US Patent  US9586962 Publication Date 3/7/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM118725
Synonyms:
US11059828, Example 378 | US11667644, Example 378 | US8653263, 378 | US9586962, Example 378 | USRE48841, Example 378
Type:
Small organic molecule
Emp. Form.:
C21H22ClN7O2
Mol. Mass.:
439.898
SMILES:
COc1ccc(C(=O)N2CC3CN(CC3C2)c2ncc(Cl)c(C)n2)c(c1)-n1nccn1
Structure:
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