Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM294927
Substrate
n/a
Meas. Tech.
Receptor Radioligand Binding Assay
Temperature
298.15±n/a K
Ki
11.0±n/a nM
Comments
extracted
Citation
 Letavic, MA; Rudolph, DA; Savall, BM; Shireman, BT; Swanson, D Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators US Patent  US9586962 Publication Date 3/7/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM294927
Synonyms:
2-(4,6-Dimethylpyrimidin-2-yl)-5-{[2-fluoro-6-(4-methoxypyrimidin-2-yl)phenyl]carbonyl}octahydropyrrolo[3,4-c]pyrrole | US9586962, Example 483 | US9586962, Example 484
Type:
Small organic molecule
Emp. Form.:
C24H25FN6O2
Mol. Mass.:
448.4927
SMILES:
COc1ccnc(n1)-c1cccc(F)c1C(=O)N1CC2CN(CC2C1)c1nc(C)cc(C)n1
Structure:
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