Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM406421
Substrate
n/a
Meas. Tech.
Intracellular cAMP Accumulation Assay
EC50
55±n/a nM
Citation
 Johnson, JA; Kim, S 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists US Patent  US10336739 Publication Date 7/2/2019 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM406421
Synonyms:
6-butyl-5-(2,6- dimethoxyphenyl)- 3-[5-(1- phenylcyclopropyl)- 1,3,4-oxadiazol-2- yl]pyridine-2,4-diol | US10336739, Example 13
Type:
Small organic molecule
Emp. Form.:
C28H29N3O5
Mol. Mass.:
487.547
SMILES:
CCCCc1nc(O)c(-c2nnc(o2)C2(CC2)c2ccccc2)c(O)c1-c1c(OC)cccc1OC |(-6.44,-1.67,;-5.11,-2.44,;-3.78,-1.67,;-2.44,-2.44,;-1.11,-1.67,;-1.11,-.13,;.22,.64,;.22,2.18,;1.56,-.13,;2.89,.64,;4.3,.01,;5.33,1.16,;4.56,2.49,;3.05,2.17,;4.96,3.98,;6.44,4.38,;5.36,5.47,;3.62,4.75,;3.62,6.29,;2.29,7.06,;.96,6.29,;.96,4.75,;2.29,3.98,;1.56,-1.67,;2.89,-2.44,;.22,-2.44,;.22,-3.98,;1.56,-4.75,;2.89,-3.98,;4.22,-4.75,;1.56,-6.29,;.22,-7.06,;-1.11,-6.29,;-1.11,-4.75,;-2.44,-3.98,;-3.78,-4.75,)|
Structure:
Search PDB for entries with ligand similarity: