Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM406464
Substrate
n/a
Meas. Tech.
Intracellular cAMP Accumulation Assay
EC50
55±n/a nM
Citation
 Johnson, JA; Kim, S 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists US Patent  US10336739 Publication Date 7/2/2019 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM406464
Synonyms:
6-butyl-5-(2,6- dimethoxyphenyl)- 3-(5-{[3-fluoro-5- (trifluoromethyl) phenyl]methyl}- 1,3,4- oxadiazol-2- yl)pyridine-2,4-diol | US10336739, Example 57
Type:
Small organic molecule
Emp. Form.:
C27H25F4N3O5
Mol. Mass.:
547.4981
SMILES:
CCCCc1nc(O)c(-c2nnc(Cc3cc(F)cc(c3)C(F)(F)F)o2)c(O)c1-c1c(OC)cccc1OC |(-8.33,-2.76,;-7,-3.53,;-5.66,-2.76,;-4.33,-3.53,;-3,-2.76,;-3,-1.22,;-1.66,-.45,;-1.66,1.09,;-.33,-1.22,;1.01,-.45,;2.41,-1.08,;3.44,.07,;2.67,1.4,;3.07,2.89,;4.56,3.29,;5.65,2.2,;7.13,2.6,;8.22,1.51,;7.53,4.09,;6.44,5.17,;4.96,4.78,;6.84,6.66,;7.24,8.15,;8.33,6.26,;5.36,7.06,;1.17,1.08,;-.33,-2.76,;1.01,-3.53,;-1.66,-3.53,;-1.66,-5.07,;-.33,-5.84,;1.01,-5.07,;2.34,-5.84,;-.33,-7.38,;-1.66,-8.15,;-3,-7.38,;-3,-5.84,;-4.33,-5.07,;-5.66,-5.84,)|
Structure:
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