Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM406472
Substrate
n/a
Meas. Tech.
Intracellular cAMP Accumulation Assay
EC50
55±n/a nM
Citation
 Johnson, JA; Kim, S 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists US Patent  US10336739 Publication Date 7/2/2019 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM406472
Synonyms:
6-butyl-5-(2,6- dimethoxyphenyl)- 3-{5-[4- (trifluoromethyl) phenoxymethyl]- 1,3,4-oxadiazol-2- yl}pyridine-2,4-diol | US10336739, Example 65
Type:
Small organic molecule
Emp. Form.:
C27H26F3N3O6
Mol. Mass.:
545.507
SMILES:
CCCCc1nc(O)c(-c2nnc(COc3ccc(cc3)C(F)(F)F)o2)c(O)c1-c1c(OC)cccc1OC |(-7.91,-3.85,;-6.57,-4.62,;-5.24,-3.85,;-3.91,-4.62,;-2.57,-3.85,;-2.57,-2.31,;-1.24,-1.54,;-1.24,0,;.09,-2.31,;1.43,-1.54,;2.83,-2.16,;3.86,-1.02,;3.09,.31,;3.49,1.8,;4.98,2.2,;5.38,3.69,;6.87,4.09,;7.27,5.57,;6.18,6.66,;4.69,6.26,;4.29,4.78,;6.57,8.15,;5.49,9.24,;7.91,8.92,;7.91,7.38,;1.59,-.01,;.09,-3.85,;1.43,-4.62,;-1.24,-4.62,;-1.24,-6.16,;.09,-6.93,;1.43,-6.16,;2.76,-6.93,;.09,-8.47,;-1.24,-9.24,;-2.57,-8.47,;-2.57,-6.93,;-3.91,-6.16,;-5.24,-6.93,)|
Structure:
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