Reaction Details Report a problem with these data
Target
Hsp90 co-chaperone Cdc37
Ligand
BDBM406707
Substrate
n/a
Meas. Tech.
Binding to JNPL3 brain Hsp90
EC50
44.5±n/a nM
Citation
 Chiosis, G; Greengard, P; Dou, F; Luo, W; He, H; Zatorska, D Treatment of neurodegenerative diseases through inhibition of HSP90 US Patent  US10336757 Publication Date 7/2/2019 
Target
Name:
Hsp90 co-chaperone Cdc37
Synonyms:
CDC37 | CDC37A | CDC37_HUMAN | Hsp90 co-chaperone
Type:
Molecular Chaperone
Mol. Mass.:
44453.72
Organism:
Homo sapiens (Human)
Description:
Q16543
Residue:
378
Sequence:
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV
  
Inhibitor
Name:
BDBM406707
Synonyms:
US10336757, Compound PU-BSI7
Type:
Small organic molecule
Emp. Form.:
C20H22FIN6O2
Mol. Mass.:
524.3306
SMILES:
CN(CCCn1c(Cc2cc3OCOc3cc2I)nc2c(N)nc(F)nc12)CC=C
Structure:
Search PDB for entries with ligand similarity: