Reaction Details Report a problem with these data
Target
Aurora kinase B
Ligand
BDBM50044657
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<100±n/a nM
Citation
 Sampson, PB; Liu, Y; Li, S; Forrest, BT; Pauls, HW; Edwards, LG; Feher, M; Patel, NK; Laufer, R Kinase inhibitors and method of treating cancer US Patent  US10358436 Publication Date 7/23/2019 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50044657
Synonyms:
CHEMBL3353347 | US10358436, Example A24 | US9907800, Example A24
Type:
Small organic molecule
Emp. Form.:
C28H26N4O
Mol. Mass.:
434.5322
SMILES:
CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: