Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase PLK4 [1-391]
Ligand
BDBM50044675
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<100±n/a nM
Citation
 Sampson, PB; Liu, Y; Li, S; Forrest, BT; Pauls, HW; Edwards, LG; Feher, M; Patel, NK; Laufer, R Kinase inhibitors and method of treating cancer US Patent  US10358436 Publication Date 7/23/2019 
Target
Name:
Serine/threonine-protein kinase PLK4 [1-391]
Synonyms:
PLK4 | PLK4_HUMAN | SAK | STK18 | Serine/threonine-protein kinase PLK4
Type:
Protein
Mol. Mass.:
43940.49
Organism:
Homo sapiens (Human)
Description:
aa 1-391
Residue:
391
Sequence:
MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQA
  
Inhibitor
Name:
BDBM50044675
Synonyms:
CHEMBL3353354 | US10358436, Example A56 | US9907800, Example A56
Type:
Small organic molecule
Emp. Form.:
C30H28N4O2
Mol. Mass.:
476.5689
SMILES:
O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccc(CN4CCOCC4)cc3)n[nH]c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: