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Target
Bile acid receptor
Ligand
BDBM408947
Substrate
n/a
Meas. Tech.
In Vitro FXR Assay (TK)
EC50
<1000±n/a nM
Citation
 Smith, ND; Govek, SP Farnesoid X receptor agonists and uses thereof US Patent  US10377717 Publication Date 8/13/2019 
Target
Name:
Bile acid receptor
Synonyms:
BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor
Type:
Nuclear Receptor
Mol. Mass.:
55916.24
Organism:
Homo sapiens (Human)
Description:
Q96RI1
Residue:
486
Sequence:
MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
  
Inhibitor
Name:
BDBM408947
Synonyms:
Methyl 1-(N-((4'-methoxy-3'-methyl-[1,1'- biphenyl]-4-yl)methyl)-4,4- dimethylpentanamido)isoquinoline-6- carboxylate | US10377717, Compound 76
Type:
Small organic molecule
Emp. Form.:
C33H36N2O4
Mol. Mass.:
524.6499
SMILES:
COC(=O)c1ccc2c(nccc2c1)N(Cc1ccc(cc1)-c1ccc(OC)c(C)c1)C(=O)CCC(C)(C)C
Structure:
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