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Target
5'-AMP-activated protein kinase catalytic subunit alpha-2
Ligand
BDBM328129
Substrate
n/a
Meas. Tech.
enzyme-linked immunosorbent assay
EC50
<500±n/a nM
Citation
 Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y AMPK-activating heterocyclic compounds and methods for using the same US Patent  US10377742 Publication Date 8/13/2019 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:
AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Type:
Enzyme
Mol. Mass.:
62331.02
Organism:
Homo sapiens (Human)
Description:
P54646
Residue:
552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
  
Inhibitor
Name:
BDBM328129
Synonyms:
N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(1-(4- cyanophenyl)piperidin- 4-ylamino)picolinamide | US10377742, Compound 267 | US9663496, Compound 267
Type:
Small organic molecule
Emp. Form.:
C31H33N7O
Mol. Mass.:
519.64
SMILES:
O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(NC2CCN(CC2)c2ccc(cc2)C#N)cn1
Structure:
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