Reaction Details Report a problem with these data
Target
5'-AMP-activated protein kinase catalytic subunit alpha-2
Ligand
BDBM328295
Substrate
n/a
Meas. Tech.
enzyme-linked immunosorbent assay
EC50
<500±n/a nM
Citation
 Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y AMPK-activating heterocyclic compounds and methods for using the same US Patent  US10377742 Publication Date 8/13/2019 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:
AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Type:
Enzyme
Mol. Mass.:
62331.02
Organism:
Homo sapiens (Human)
Description:
P54646
Residue:
552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
  
Inhibitor
Name:
BDBM328295
Synonyms:
6-(4-(3-(cyclopropane- carboxamido)phenoxy) piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide | US10377742, Compound 433 | US9663496, Compound 433
Type:
Small organic molecule
Emp. Form.:
C33H30FN5O5
Mol. Mass.:
595.6202
SMILES:
Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3cccc(NC(=O)C4CC4)c3)cn2)cc1
Structure:
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