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Target
Equilibrative nucleoside transporter 1
Ligand
BDBM409033
Substrate
n/a
Meas. Tech.
Determination of Adenosine Transport Activity
IC50
32.1±n/a nM
Citation
 Gaufreteau, D; Hilpert, H; Humm, R; Kolczewski, S; Muser, T; Plancher, J; Stoll, T Indolin-2-one derivatives US Patent  US10377746 Publication Date 8/13/2019 
Target
Name:
Equilibrative nucleoside transporter 1
Synonyms:
ENT-1 transporter | Ent1 | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | S29A1_MOUSE | Slc29a1 | Solute carrier family 29 member 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50202.32
Organism:
Mus musculus (Mouse)
Description:
Q9JIM1
Residue:
460
Sequence:
MTTSHQPQDRYKAVWLIFFVLGLGTLLPWNFFMTATKYFTNRLDVSQNVSSDTDQSCESTKALADPTVALPARSSLSAIFNNVMTLCAMLPLLVFTCLNSFLHQRISQSVRILGSLLAILLVFLVTAALVKVEMDALIFFVITMIKIVLINSFGAILQASLFGLAGVLPANYTAPIMSGQGLAGFFTSVAMICAIASGSELSESAFGYFITACAVVILAILCYLALPRTEFYRHYLQLNLAGPAEQETKLDLISKGEEPKGRREESGVPGPNSPPTNRNQSIKAILKSICVPALSVCFIFTVTIGLFPAVTAEVESSIAGTSPWKSYFIPVACFLNFNVFDWLGRSLTAVCMWPGQDSRWLPVLVASRIVFIPLLMLCNVKARHCGAQRHHFVFKHDAWFIAFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGNIMSFFLCLGLALGAVLSFLLRALV
  
Inhibitor
Name:
BDBM409033
Synonyms:
3,3-Dimethyl-6-(2-methylpyrimidin-5-yl)-1-(5-(methylsulfonyl)pyridin-3-yl)indolin-2-one | US10377746, Expl. 3
Type:
Small organic molecule
Emp. Form.:
C21H20N4O3S
Mol. Mass.:
408.473
SMILES:
Cc1ncc(cn1)-c1ccc2c(c1)N(C(=O)C2(C)C)c1cncc(c1)S(C)(=O)=O
Structure:
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