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Target
Equilibrative nucleoside transporter 1
Ligand
BDBM409051
Substrate
n/a
Meas. Tech.
Determination of Adenosine Transport Activity
IC50
218±n/a nM
Citation
 Gaufreteau, D; Hilpert, H; Humm, R; Kolczewski, S; Muser, T; Plancher, J; Stoll, T Indolin-2-one derivatives US Patent  US10377746 Publication Date 8/13/2019 
Target
Name:
Equilibrative nucleoside transporter 1
Synonyms:
ENT-1 transporter | Ent1 | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | S29A1_MOUSE | Slc29a1 | Solute carrier family 29 member 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50202.32
Organism:
Mus musculus (Mouse)
Description:
Q9JIM1
Residue:
460
Sequence:
MTTSHQPQDRYKAVWLIFFVLGLGTLLPWNFFMTATKYFTNRLDVSQNVSSDTDQSCESTKALADPTVALPARSSLSAIFNNVMTLCAMLPLLVFTCLNSFLHQRISQSVRILGSLLAILLVFLVTAALVKVEMDALIFFVITMIKIVLINSFGAILQASLFGLAGVLPANYTAPIMSGQGLAGFFTSVAMICAIASGSELSESAFGYFITACAVVILAILCYLALPRTEFYRHYLQLNLAGPAEQETKLDLISKGEEPKGRREESGVPGPNSPPTNRNQSIKAILKSICVPALSVCFIFTVTIGLFPAVTAEVESSIAGTSPWKSYFIPVACFLNFNVFDWLGRSLTAVCMWPGQDSRWLPVLVASRIVFIPLLMLCNVKARHCGAQRHHFVFKHDAWFIAFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGNIMSFFLCLGLALGAVLSFLLRALV
  
Inhibitor
Name:
BDBM409051
Synonyms:
3,3-Dimethyl-6-(2-methyl-1-oxidopyrimidin-1-ium-5-yl)-1-(6-methylsulfonylpyrazin-2-yl)indol-2-one | US10377746, Expl. 15
Type:
Small organic molecule
Emp. Form.:
C20H19N5O4S
Mol. Mass.:
425.461
SMILES:
Cc1c[n+]([O-])c(cn1)-c1ccc2c(c1)N(C(=O)C2(C)C)c1cncc(n1)S(C)(=O)=O
Structure:
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