Reaction Details Report a problem with these data
Target
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Ligand
BDBM409965
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
Ki
29.0±n/a nM
Citation
 Converso, A; Kaufman, ML; Rodzinak, K Oxy-cyanoquinolinone PDE9 inhibitors US Patent  US10370337 Publication Date 8/6/2019 
Target
Name:
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Synonyms:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A (PDE9A2) | Phosphodiesterase 9A2
Type:
Protein
Mol. Mass.:
61702.98
Organism:
Homo sapiens (Human)
Description:
O76083-2
Residue:
533
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
  
Inhibitor
Name:
BDBM409965
Synonyms:
4-(cycloheptyl- oxy)-2-oxo-1,2- dihydro- quinoline-3- carbonitrile | US10370337, Example 1-8
Type:
Small organic molecule
Emp. Form.:
C17H18N2O2
Mol. Mass.:
282.337
SMILES:
O=c1[nH]c2ccccc2c(OC2CCCCCC2)c1C#N
Structure:
Search PDB for entries with ligand similarity: