Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM410107
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
>10000±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM410107
Synonyms:
US10370370, Compound 6-P2
Type:
Small organic molecule
Emp. Form.:
C17H21N3O
Mol. Mass.:
283.3681
SMILES:
C1CC1c1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1 |r,wD:9.9,(9.83,-3.39,;9.51,-1.89,;8.37,-2.92,;6.86,-3.24,;5.83,-2.09,;4.33,-2.41,;3.85,-3.88,;2.44,-4.51,;1.11,-3.74,;-.22,-4.51,;-.22,-6.05,;-1.56,-6.82,;-2.89,-6.05,;-2.89,-4.51,;-1.56,-3.74,;-.79,-5.07,;-2.28,-5.47,;2.6,-6.04,;4.11,-6.36,;4.88,-5.02,;6.39,-4.7,)|
Structure:
Search PDB for entries with ligand similarity: