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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM410108
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
740±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM410108
Synonyms:
US10370370, Compound 7-P1
Type:
Small organic molecule
Emp. Form.:
C15H19N3O2
Mol. Mass.:
273.3303
SMILES:
COc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1 |r,wU:8.7,(9.52,-1.64,;9.04,-3.1,;7.54,-3.42,;6.5,-2.28,;5,-2.6,;4.52,-4.06,;3.12,-4.69,;1.78,-3.92,;.45,-4.69,;.45,-6.23,;-.89,-7,;-2.22,-6.23,;-2.22,-4.69,;-.89,-3.92,;-.12,-5.25,;-1.6,-5.65,;3.28,-6.22,;4.78,-6.54,;5.55,-5.2,;7.06,-4.88,)|
Structure:
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