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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM410120
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
930±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM410120
Synonyms:
US10370370, Compound (R)-15
Type:
Small organic molecule
Emp. Form.:
C14H15Cl2N3O
Mol. Mass.:
312.194
SMILES:
Clc1cc2onc(N[C@H]3CN4CCC3CC4)c2cc1Cl |r,wU:8.7,TLB:7:8:11.12:14.15,(2.45,-.87,;1.09,-1.38,;.84,-2.89,;-.6,-3.43,;-1.41,-4.89,;-2.86,-4.81,;-3.09,-3.28,;-4.52,-2.72,;-5.73,-3.68,;-5.44,-5.1,;-6.84,-4.46,;-6.58,-2.52,;-7.03,-1.39,;-7.11,-3.06,;-8.61,-3.72,;-8.41,-5.13,;-1.79,-2.46,;-1.54,-.94,;-.1,-.4,;.14,1.04,)|
Structure:
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