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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM410136
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
925±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM410136
Synonyms:
US10370370, Compound (R)-29
Type:
Small organic molecule
Emp. Form.:
C15H18FN3O2
Mol. Mass.:
291.3207
SMILES:
COc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1F |r,wU:8.7,TLB:7:8:11.12:14.15,(3.32,1.08,;3.08,-.36,;1.72,-.87,;.54,.11,;-.91,-.43,;-1.16,-1.95,;-2.46,-2.77,;-3.89,-2.21,;-5.1,-3.17,;-4.81,-4.59,;-6.21,-3.95,;-5.95,-2.01,;-6.4,-.88,;-6.47,-2.55,;-7.97,-3.21,;-7.77,-4.62,;-2.23,-4.3,;-.78,-4.39,;.03,-2.92,;1.47,-2.38,;2.59,-3.31,)|
Structure:
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