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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM410146
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
9000±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM410146
Synonyms:
US10370370, Compound (R)-37
Type:
Small organic molecule
Emp. Form.:
C17H20FN5O2
Mol. Mass.:
345.3714
SMILES:
Cc1nnc(o1)-c1ccc(\C(N[C@H]2CN3CCC2CC3)=N\O)c(F)c1 |r,wU:12.12,TLB:11:12:15.16:18.19,(2.14,5.1,;1.73,3.61,;2.69,2.41,;1.84,1.12,;.36,1.53,;.29,3.07,;-.84,.57,;-.62,-.95,;-1.82,-1.91,;-3.25,-1.35,;-4.46,-2.31,;-5.89,-1.74,;-7.1,-2.7,;-6.81,-4.13,;-8.21,-3.48,;-7.95,-1.54,;-8.4,-.41,;-8.47,-2.08,;-9.97,-2.74,;-9.77,-4.15,;-4.23,-3.83,;-5.43,-4.79,;-3.48,.18,;-4.92,.74,;-2.28,1.14,)|
Structure:
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