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Target
Non-receptor tyrosine-protein kinase TYK2 [888-1187]
Ligand
BDBM410157
Substrate
n/a
Meas. Tech.
Caliper mobility shift assay
IC50
>10000±n/a nM
Citation
 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Heterocyclyl-substituted cyclohexylsulfonamides as JAK inhibitors US Patent  US10370375 Publication Date 8/6/2019 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [888-1187]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (aa 888-1187) | TYK2 | TYK2 (aa 888-1187) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
34527.73
Organism:
Homo sapiens (Human)
Description:
P29597[888-1187]
Residue:
300
Sequence:
DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM410157
Synonyms:
US10370375, Example 5
Type:
Small organic molecule
Emp. Form.:
C21H28N6O2S
Mol. Mass.:
428.551
SMILES:
CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(Cc3ccccc3)nc12 |r,wD:6.5,(4.29,4.1,;4.29,5.64,;2.96,6.41,;1.63,7.18,;4.29,7.18,;2.96,4.87,;1.63,4.1,;.29,4.87,;-1.04,4.1,;-1.04,2.56,;.29,1.79,;1.63,2.56,;-2.37,1.79,;-3.71,2.56,;-2.37,.25,;-3.71,-.52,;-3.71,-2.06,;-2.37,-2.83,;-1.04,-2.06,;.42,-2.54,;1.33,-1.29,;2.87,-1.29,;3.64,-2.63,;2.87,-3.96,;3.64,-5.29,;5.18,-5.29,;5.95,-3.96,;5.18,-2.63,;.42,-.05,;-1.04,-.52,)|
Structure:
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