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Target
Non-receptor tyrosine-protein kinase TYK2 [888-1187]
Ligand
BDBM410164
Substrate
n/a
Meas. Tech.
Caliper mobility shift assay
IC50
>10000±n/a nM
Citation
 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Heterocyclyl-substituted cyclohexylsulfonamides as JAK inhibitors US Patent  US10370375 Publication Date 8/6/2019 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [888-1187]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (aa 888-1187) | TYK2 | TYK2 (aa 888-1187) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
34527.73
Organism:
Homo sapiens (Human)
Description:
P29597[888-1187]
Residue:
300
Sequence:
DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM410164
Synonyms:
US10370375, Example 12
Type:
Small organic molecule
Emp. Form.:
C13H23N5O2S
Mol. Mass.:
313.419
SMILES:
CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1C |r,wD:6.5,(4.29,4.1,;4.29,5.64,;2.96,6.41,;1.63,7.18,;4.29,7.18,;2.96,4.87,;1.63,4.1,;.29,4.87,;-1.04,4.1,;-1.04,2.56,;.29,1.79,;1.63,2.56,;-2.38,1.79,;-2.38,.25,;-1.04,-.52,;-1.04,-2.06,;.29,-2.83,;-2.38,-2.83,;-3.71,-2.06,;-3.71,-.52,;-5.04,.25,)|
Structure:
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