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Target
Tyrosine-protein kinase JAK3 [811-1124]
Ligand
BDBM410172
Substrate
n/a
Meas. Tech.
Caliper mobility shift assay
IC50
>10000±n/a nM
Citation
 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Heterocyclyl-substituted cyclohexylsulfonamides as JAK inhibitors US Patent  US10370375 Publication Date 8/6/2019 
Target
Name:
Tyrosine-protein kinase JAK3 [811-1124]
Synonyms:
JAK3 | JAK3 (aa 811-1124) | JAK3_HUMAN | Tyrosine-protein kinase JAK3 (aa 811-1124)
Type:
Protein
Mol. Mass.:
35601.85
Organism:
Homo sapiens (Human)
Description:
P52333[811-1124]
Residue:
314
Sequence:
CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM410172
Synonyms:
US10370375, Example 20
Type:
Small organic molecule
Emp. Form.:
C17H20N2O3S2
Mol. Mass.:
364.482
SMILES:
CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1c(cnc2sccc12)C#C |r,wU:6.5,(4.29,4.1,;4.29,5.64,;2.96,6.41,;1.63,7.18,;4.29,7.18,;2.96,4.87,;1.63,4.1,;1.63,2.56,;.29,1.79,;-1.04,2.56,;-1.04,4.1,;.29,4.87,;-2.38,1.79,;-2.38,.25,;-3.71,-.52,;-3.71,-2.06,;-2.38,-2.83,;-1.04,-2.06,;.42,-2.54,;1.33,-1.29,;.42,-.05,;-1.04,-.52,;-5.04,.25,;-6.38,-.52,)|
Structure:
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