Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM344021
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
>500000±n/a nM
Citation
 Li, Y; Zhu, W; Mei, S Tricyclic fused thiophene derivatives as JAK inhibitors US Patent  US10370387 Publication Date 8/6/2019 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (aa 828-1132)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35522.23
Organism:
Homo sapiens (Human)
Description:
aa 828-1132
Residue:
304
Sequence:
ALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM344021
Synonyms:
US10370387, Example 5 | US11161855, Example 5 | US9777017, Example 5 | US9908895, Example 5
Type:
Small organic molecule
Emp. Form.:
C19H25N3O3S2
Mol. Mass.:
407.55
SMILES:
C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CCS(C)(=O)=O)CC1 |r,wU:1.1,15.17,wD:18.21,(-5.93,.72,;-4.39,.72,;-3.62,2.05,;-3.62,-.61,;-4.25,-2.02,;-3.1,-3.05,;-3.1,-4.59,;-1.77,-5.36,;-.44,-4.59,;1.03,-5.07,;1.93,-3.82,;1.03,-2.57,;-.44,-3.05,;-1.77,-2.28,;-2.09,-.77,;-1,.31,;-1.4,1.8,;-.31,2.89,;1.18,2.49,;2.27,3.58,;3.75,3.18,;4.84,4.27,;5.93,3.18,;5.93,5.36,;3.75,5.36,;1.58,1.01,;.49,-.08,)|
Structure:
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