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Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM344043
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<1000±n/a nM
Citation
 Li, Y; Zhu, W; Mei, S Tricyclic fused thiophene derivatives as JAK inhibitors US Patent  US10370387 Publication Date 8/6/2019 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (aa 828-1132)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35522.23
Organism:
Homo sapiens (Human)
Description:
aa 828-1132
Residue:
304
Sequence:
ALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM344043
Synonyms:
US10370387, Example 27 | US11161855, Example 27 | US9777017, Example 27 | US9908895, Example 27
Type:
Small organic molecule
Emp. Form.:
C19H22N4S
Mol. Mass.:
338.47
SMILES:
CC(C)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:15.17,wD:18.21,(-4.15,3.15,;-4.15,1.61,;-5.48,2.38,;-3.38,.28,;-4.01,-1.13,;-2.86,-2.16,;-2.86,-3.7,;-1.53,-4.47,;-.19,-3.7,;1.27,-4.18,;2.18,-2.93,;1.27,-1.69,;-.19,-2.16,;-1.53,-1.39,;-1.85,.12,;-.76,1.2,;-1.16,2.69,;-.07,3.78,;1.42,3.38,;2.51,4.47,;4,4.07,;5.48,3.68,;1.82,1.89,;.73,.81,)|
Structure:
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