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Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM410241
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<100±n/a nM
Citation
 Li, Y; Zhu, W; Mei, S Tricyclic fused thiophene derivatives as JAK inhibitors US Patent  US10370387 Publication Date 8/6/2019 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM410241
Synonyms:
((1R,2R,4S)-2-Hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile and ((1S,2S,4R)-2-hydroxy-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile | US10370387, Example 36 | US11161855, Example 36 (first peak)
Type:
Small organic molecule
Emp. Form.:
C18H20N4O2S
Mol. Mass.:
356.442
SMILES:
C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CC#N)[C@H](O)C1 |r|
Structure:
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