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Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM344081
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
>500000±n/a nM
Citation
 Li, Y; Zhu, W; Mei, S Tricyclic fused thiophene derivatives as JAK inhibitors US Patent  US10370387 Publication Date 8/6/2019 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (aa 828-1132)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35522.23
Organism:
Homo sapiens (Human)
Description:
aa 828-1132
Residue:
304
Sequence:
ALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM344081
Synonyms:
US10370387, Example 65 | US11161855, Example 65 | US9777017, Example 65 | US9908895, Example 65
Type:
Small organic molecule
Emp. Form.:
C18H21N5OS
Mol. Mass.:
355.457
SMILES:
C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CCN(CCCC#N)C1 |r|
Structure:
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