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Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM344097
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
>2000±n/a nM
Citation
 Li, Y; Zhu, W; Mei, S Tricyclic fused thiophene derivatives as JAK inhibitors US Patent  US10370387 Publication Date 8/6/2019 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (aa 828-1132)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35522.23
Organism:
Homo sapiens (Human)
Description:
aa 828-1132
Residue:
304
Sequence:
ALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM344097
Synonyms:
US10370387, Example 81 | US11161855, Example 81 | US9777017, Example 81 | US9908895, Example 81
Type:
Small organic molecule
Emp. Form.:
C20H27N5O2S
Mol. Mass.:
401.526
SMILES:
C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CNC(=O)N(C)C)CC1 |r,wU:15.17,1.1,wD:18.21,(-6.13,-.02,;-4.59,-.02,;-3.82,1.31,;-3.82,-1.36,;-4.45,-2.76,;-3.3,-3.79,;-3.3,-5.33,;-1.97,-6.1,;-.64,-5.33,;.83,-5.81,;1.73,-4.56,;.83,-3.32,;-.64,-3.79,;-1.97,-3.02,;-2.29,-1.52,;-1.2,-.43,;-1.6,1.06,;-.51,2.15,;.98,1.75,;2.07,2.84,;3.55,2.44,;4.64,3.53,;6.13,3.13,;4.24,5.02,;5.33,6.1,;2.76,5.41,;1.38,.26,;.29,-.83,)|
Structure:
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