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Target
Type-2 angiotensin II receptor
Ligand
BDBM318803
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
IC50
314±n/a nM
Citation
McCarthy, TD; Naylor, A Heterocyclic compounds and methods of their use US Patent US10370388 Publication Date 8/6/2019
More Info.:
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
Inhibitor
Name:
BDBM318803
Synonyms:
(2S,4S)-4-((benzylsulfonyl)methyl)-1-(diphenylacetyl)-pyrrolidine-2-carboxylic acid | US10370388, Compound 118 | US9624243, 118
Type:
Small organic molecule
Emp. Form.:
C27H27NO5S
Mol. Mass.:
477.572
SMILES:
OC(=O)[C@@H]1C[C@H](CS(=O)(=O)Cc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1