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Target
Type-2 angiotensin II receptor
Ligand
BDBM318764
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
IC50
372±n/a nM
Citation
 McCarthy, TD; Naylor, A Heterocyclic compounds and methods of their use US Patent  US10370388 Publication Date 8/6/2019 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM318764
Synonyms:
1-((2R,3S)-2-(hydroxymethyl)-3-(3-phenylpropoxy)-azetidin-1-yl)-2,2-diphenylethanone and 14(2S,3R)-2-(hydroxymethyl)-3-(3-phenylpropoxy)-azetidin-1-yl)-2,2-diphenylethanone | US10370388, Compound 143 | US9624243, 56
Type:
Small organic molecule
Emp. Form.:
C27H27NO4
Mol. Mass.:
429.5076
SMILES:
OC(=O)[C@H]1[C@@H](CN1C(=O)C(c1ccccc1)c1ccccc1)OCCCc1ccccc1 |r|
Structure:
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