Target
Nuclear receptor ROR-gamma
Ligand
BDBM310102
Substrate
n/a
Meas. Tech.
RORgamma-Ligand Binding Domain TR-FRET Assay Protocol I
EC50
336±n/a nM
Citation
 Aicher, TDBarr, KJLapointe, BTSimov, VStein, KAThomas, WDToogood, PLVan Huis, CAWhite, CM Tetrahydronaphthyridine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease US Patent  US10377768 Publication Date 8/13/2019 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM310102
Synonyms:
(S)-N-(3-(acetamidomethyl)-1-(m-tolylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-2-chloro-6-fluorobenzamide | US10377768, Compound 16 | US9657033, Compound 16
Type:
Small organic molecule
Emp. Form.:
C24H22ClFN4O5S
Mol. Mass.:
532.972
SMILES:
CC(=O)NC[C@H]1CN(c2cc(NC(=O)c3c(F)cccc3Cl)cnc2O1)S(=O)(=O)c1cccc(C)c1 |r|
Structure:
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