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Target
G-protein coupled bile acid receptor 1
Ligand
BDBM410920
Substrate
n/a
Meas. Tech.
cAMP Assay
EC50
29.0±n/a nM
Citation
 Bissantz, C; Dehmlow, H; Erickson, SD; Karnachi, PS; Kim, K; Martin, RE; Mattei, P; Sander, UO; Pietranico-Cole, SL; Richter, H; Ullmer, C 3-amino-pyridines as GPBAR1 agonists US Patent  US10385022 Publication Date 8/20/2019 
Target
Name:
G-protein coupled bile acid receptor 1
Synonyms:
BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
35260.02
Organism:
Homo sapiens (Human)
Description:
CHO cells transiently transfected with hTGR5.
Residue:
330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
  
Inhibitor
Name:
BDBM410920
Synonyms:
N-Methyl-N-[4-(2-trifluoromethoxy-phenyl)-pyridin-3-yl]-3,5-bis-trifluoromethyl-benzamide | US10385022, Example 31
Type:
Small organic molecule
Emp. Form.:
C22H13F9N2O2
Mol. Mass.:
508.3364
SMILES:
CN(C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1cnccc1-c1ccccc1OC(F)(F)F
Structure:
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