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Target
Histone deacetylase 2
Ligand
BDBM411377
Substrate
n/a
Meas. Tech.
Enzyme Assays
IC50
<1000±n/a nM
Citation
 van Duzer, JH; Mazitschek, R Substituted piperazines as selective HDAC1,2 inhibitors US Patent  US10385031 Publication Date 8/20/2019 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM411377
Synonyms:
US10385031, Compound 083 | US10774056, Compound 083 | US11542242, Compound 083
Type:
Small organic molecule
Emp. Form.:
C21H23N5O2
Mol. Mass.:
377.4396
SMILES:
CN1CCN(CC1)c1ccc(nc1)C(=O)Nc1cc(ccc1N)-c1ccoc1
Structure:
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