Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50043691
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
IC50
132±n/a nM
Citation
 Xu, YBrenning, BGKultgen, SGLiu, XSaunders, MDHo, K Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors US Patent  US10392392 Publication Date 8/27/2019 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50043691
Synonyms:
CHEMBL3355543 | US10047093, 8-53 | US10392392, Example 8-53 | US10875864, EX. 8-53 | US9416132, 8-53
Type:
Small organic molecule
Emp. Form.:
C18H18F3N5O
Mol. Mass.:
377.3636
SMILES:
N[C@H]1CCCN(C1)c1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r|
Structure:
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