Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50043697
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
IC50
23.0±n/a nM
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, MD; Ho, K Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors US Patent  US10392392 Publication Date 8/27/2019 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50043697
Synonyms:
CHEMBL3355987 | US10047093, 8-63 | US10392392, Example 8-63 | US10875864, EX. 8-63 | US9416132, 8-63
Type:
Small organic molecule
Emp. Form.:
C21H25ClN4O
Mol. Mass.:
384.902
SMILES:
CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r,wU:4.3,wD:7.10,(.73,-52.37,;1.51,-51.04,;-.05,-51.03,;1.52,-49.51,;2.84,-51.82,;4.18,-51.06,;5.51,-51.82,;5.5,-53.37,;4.18,-54.14,;2.84,-53.36,;6.84,-54.14,;8.17,-53.37,;8.17,-51.83,;9.5,-51.05,;10.83,-51.83,;12.29,-51.35,;13.2,-52.6,;12.29,-53.84,;13.05,-55.17,;12.26,-56.5,;13.02,-57.84,;14.56,-57.86,;15.34,-56.52,;16.88,-56.53,;14.58,-55.19,;10.83,-53.37,;9.5,-54.13,)|
Structure:
Search PDB for entries with ligand similarity: