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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242400
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
IC50
89.0±n/a nM
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, MD; Ho, K Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors US Patent  US10392392 Publication Date 8/27/2019 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242400
Synonyms:
US10047093, 8-83 | US10392392, Example 8-83 | US10875864, EX. 8-83 | US9416132, 8-83
Type:
Small organic molecule
Emp. Form.:
C19H20ClN5O
Mol. Mass.:
369.848
SMILES:
Clc1cccc(c1)-c1cnc2ccc(N[C@H]3CC[C@@H](CC3)NC=O)nn12 |r,wU:18.22,wD:15.15,(7.95,-2.93,;6.47,-2.54,;5.38,-3.62,;3.89,-3.23,;3.49,-1.74,;4.58,-.65,;6.07,-1.05,;4.18,.84,;5.09,2.08,;4.18,3.33,;2.72,2.85,;1.38,3.62,;.05,2.85,;.05,1.31,;-1.28,.54,;-2.62,1.31,;-2.62,2.85,;-3.95,3.62,;-5.29,2.85,;-5.29,1.31,;-3.95,.54,;-6.62,3.62,;-7.95,2.85,;-7.95,1.31,;1.38,.54,;2.72,1.31,)|
Structure:
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