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Target
Programmed cell death 1 ligand 1
Ligand
BDBM412160
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay - ELISA
IC50
<100±n/a nM
Citation
 Malathong, V; McMahon, J; McMurtrie, DJ; Punna, S; Roth, HS; Singh, R; Zhang, P Macrocyclic immunomodulators US Patent  US10392405 Publication Date 8/27/2019 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM412160
Synonyms:
US10392405, Compound Id 1.024 | US11059834, Compound 1.024
Type:
Small organic molecule
Emp. Form.:
C42H51ClN4O6
Mol. Mass.:
743.331
SMILES:
Cc1c(COc2cc3OCc4cncc(c4)C(=O)NCCCC[C@@H](CO)NCc3cc2Cl)cccc1-c1cccc(OCCCN2CC[C@@H](O)C2)c1C |r|
Structure:
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