Reaction Details Report a problem with these data
Target
Baculoviral IAP repeat-containing protein 2 [174-256]
Ligand
BDBM412166
Substrate
n/a
Meas. Tech.
TR-FRET Assays for cIAP BIR2
IC50
2280±n/a nM
Citation
 Flohr, A; Galley, G; Norcross, R; Zorn, N Dimeric compounds US Patent  US10398702 Publication Date 9/3/2019 
Target
Name:
Baculoviral IAP repeat-containing protein 2 [174-256]
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | CIAP Bir2 | MIHB | RNF48
Type:
Enzyme Catalytic Domain
Mol. Mass.:
9527.07
Organism:
Homo sapiens (Human)
Description:
Q13490[174-256]
Residue:
83
Sequence:
TNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLET
  
Inhibitor
Name:
BDBM412166
Synonyms:
(3S)-2-((S)-3,3-dimethyl-2- ((S)-2- (methylamino)propanamido) butanoyl)-7-(6-(4- fluorobenzyl)-3-methyl-1-(2- ((2R,5R)-5-methyl-2-(((R)- 3-methylmorpholino)methyl) piperazin-1- yl)acetypindoline-3- carboxamido)-N-((R)- 1,2,3,4-tetrahydronaphthalen- 1-yl)-1,2,3,4- tetrahydroisoquinoline-3- carboxamide trihydrochloride | US10398702, Example 5
Type:
Small organic molecule
Emp. Form.:
C60H78FN9O6
Mol. Mass.:
1040.3164
SMILES:
CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)C3(C)CN(C(=O)CN4C[C@@H](C)NC[C@@H]4CN4CCOC[C@H]4C)c4cc(Cc5ccc(F)cc5)ccc34)ccc2CC1C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C |r|
Structure:
Search PDB for entries with ligand similarity: