Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM412890
Substrate
n/a
Meas. Tech.
Patch-Clamp Assay for Inhibitory Activity on Kv1.3
IC50
<500±n/a nM
Citation
 Tasler, S; Krimmelbein, I Kv1.3 inhibitors and their medical applications US Patent  US10399991 Publication Date 9/3/2019 
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM412890
Synonyms:
US10399991, Example 7 | US10822345, Ex 7
Type:
Small organic molecule
Emp. Form.:
C21H18O4
Mol. Mass.:
334.3652
SMILES:
COc1ccccc1-c1c(C)c(=O)oc2c(C)c3occ(C)c3cc12 |(5.19,2.31,;3.85,1.54,;2.52,2.31,;2.52,3.85,;1.18,4.62,;-.15,3.85,;-.15,2.31,;1.18,1.54,;1.18,,;2.52,-.77,;3.85,,;2.52,-2.31,;3.85,-3.08,;1.18,-3.08,;-.15,-2.31,;-1.48,-3.08,;-1.48,-4.62,;-2.82,-2.31,;-4.28,-2.79,;-5.19,-1.54,;-4.28,-.29,;-4.76,1.17,;-2.82,-.77,;-1.48,,;-.15,-.77,)|
Structure:
Search PDB for entries with ligand similarity: