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TargetG-protein coupled receptor 6
LigandBDBM191037
Substrate/Competitorn/a
Meas. Tech.Competition Binding Assay
IC50 505±n/a nM
Citation Brown, JWHitchcock, SHopkins, MKikuchi, SMonenschein, HReichard, HSchleicher, KSun, HMacklin, T Tetrahydropyridopyrazine modulators of GPR6 US Patent US10406157 Publication Date 9/10/2019
More Info.:Get all data from this article,  Assay Method
 
G-protein coupled receptor 6
Name:G-protein coupled receptor 6
Synonyms:G-protein coupled receptor 6 (GPR6) | GPR6 | Sphingosine 1-phosphate receptor GPR6
Type:Protein
Mol. Mass.:37886.39
Organism:Homo sapiens (Human)
Description:P46095
Residue:362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL
SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL
AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI
MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV
VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS
EV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM191037
NameBDBM191037
Synonyms:US10077266, Example 149 | US10406157, Compound A | US9181249, 149 | US9708313, 149
TypeSmall organic molecule
Emp. Form.C24H29F2N5O3
Mol. Mass.473.5156
SMILESCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@H]3CCOC3)nc2C1 |r|
Structure
n/a