Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [181-417]
Ligand
BDBM413221
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
3.98±n/a nM
Citation
 Brown, JW; Davis, M; Ivetac, A; Jones, B; Kiryanov, AA; Kuehler, J; Lanier, M; Miura, J; Murphy, S; Wang, X 6-(5-hydroxy-1H-pyrazol-1-yl)nicotinamide inhibitors of PHD US Patent  US10407409 Publication Date 9/10/2019 
Target
Name:
Egl nine homolog 1 [181-417]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (aa 181-417)
Type:
Enzyme
Mol. Mass.:
26555.51
Organism:
Homo sapiens (Human)
Description:
aa 181-417
Residue:
237
Sequence:
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKP
  
Inhibitor
Name:
BDBM413221
Synonyms:
(R)-4-(1-(5-(4-ethyl-3-methylpiperazine-1-carbonyl)pyridin-2-yl)-5-hydroxy-1H-pyrazol-4-yl)-2-fluoro-3-methylbenzonitrile | US10407409, Example 338
Type:
Small organic molecule
Emp. Form.:
C24H25FN6O2
Mol. Mass.:
448.4927
SMILES:
CCN1CCN(C[C@H]1C)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(C#N)c(F)c1C |r|
Structure:
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