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TargetJAK2 (aa808-1132)
LigandBDBM50332294
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
pH7.5±n/a
IC50 8.00±n/a nM
Commentsextracted
Citation Bursulaya, BFisch, ALajiness, JPMachauer, RMalekar, SPetrassi, HMRamazani, FRemond, AUllrich, TUsselmann, PVangrevelinghe, E Substituted indazoles for treating tendon and/or ligament injuries US Patent US10112907 Publication Date 10/30/2018
More Info.:Get all data from this article,  Assay Method
 
JAK2 (aa808-1132)
Name:JAK2 (aa808-1132)
Synonyms:n/a
Type:Protein
Mol. Mass.:39171.39
Organism:Homo sapiens (Human)
Description:n/a
Residue:335
Sequence:
FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGK
GNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVC
YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDL
ATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDE
IYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50332294
NameBDBM50332294
Synonyms:CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide | US10112907, Example 00018
TypeSmall organic molecule
Emp. Form.C27H36N6O3S
Mol. Mass.524.678
SMILESCc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a