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TargetJAK2 (aa808-1132)
LigandBDBM50311017
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
pH7.5±n/a
IC50 20.0±n/a nM
Commentsextracted
Citation Bursulaya, BFisch, ALajiness, JPMachauer, RMalekar, SPetrassi, HMRamazani, FRemond, AUllrich, TUsselmann, PVangrevelinghe, E Substituted indazoles for treating tendon and/or ligament injuries US Patent US10112907 Publication Date 10/30/2018
More Info.:Get all data from this article,  Assay Method
 
JAK2 (aa808-1132)
Name:JAK2 (aa808-1132)
Synonyms:n/a
Type:Protein
Mol. Mass.:39171.39
Organism:Homo sapiens (Human)
Description:n/a
Residue:335
Sequence:
FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGK
GNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVC
YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDL
ATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDE
IYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50311017
NameBDBM50311017
Synonyms:CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide | US10112907, Example 00019 | US9469613, CYT-0387
TypeSmall organic molecule
Emp. Form.C23H22N6O2
Mol. Mass.414.4598
SMILESO=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a