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Target
Non-receptor tyrosine-protein kinase TYK2 [888-1187]
Ligand
BDBM50311017
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±n/a
IC50
30.0±n/a nM
Comments
extracted
Citation
 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Substituted indazoles for treating tendon and/or ligament injuries US Patent  US10112907 Publication Date 10/30/2018 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [888-1187]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (aa 888-1187) | TYK2 | TYK2 (aa 888-1187) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
34527.73
Organism:
Homo sapiens (Human)
Description:
P29597[888-1187]
Residue:
300
Sequence:
DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM50311017
Synonyms:
CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide | US10112907, Example 00019 | US10766894, Compound TABLE 1.4 | US11203595, TABLE 1.4 | US9469613, CYT-0387
Type:
Small organic molecule
Emp. Form.:
C23H22N6O2
Mol. Mass.:
414.4598
SMILES:
O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Structure:
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