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Target
Tyrosine-protein kinase JAK2 [808-1132]
Ligand
BDBM147692
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±n/a
IC50
2700±n/a nM
Comments
extracted
Citation
 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Substituted indazoles for treating tendon and/or ligament injuries US Patent  US10112907 Publication Date 10/30/2018 
Target
Name:
Tyrosine-protein kinase JAK2 [808-1132]
Synonyms:
JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132)
Type:
Protein
Mol. Mass.:
39171.39
Organism:
Homo sapiens (Human)
Description:
O60674[808-1132]
Residue:
335
Sequence:
FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM147692
Synonyms:
US10112907, Example 00025 | US8962608, 28-1
Type:
Small organic molecule
Emp. Form.:
C21H23F3N6O
Mol. Mass.:
432.4421
SMILES:
NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@H]1CC[C@@H](C[C@@H]1[N+]#[C-])N1CCC1 |r|
Structure:
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