Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [368-440]
Ligand
BDBM223492
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
0.427±n/a nM
Citation
 Bradner, JE; Qi, J Compositions and methods for treating neoplasia, inflammatory disease and other disorders US Patent  US10407441 Publication Date 9/10/2019 
Target
Name:
Bromodomain-containing protein 4 [368-440]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 2 | Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 (BRD4) Bromo 2 | Bromodomain-containing protein 4 (BRD4)(BD2) | Bromodomain-containing protein 4 (BRD4)(Bromo 2) | Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2 | HUNK1
Type:
Protein
Mol. Mass.:
8564.63
Organism:
Homo sapiens (Human)
Description:
BD2 (368-440 aa) of O60885
Residue:
73
Sequence:
KHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVV
  
Inhibitor
Name:
BDBM223492
Synonyms:
US10407441, Compound JQ8 | US10925881, Name (S)-JQ8 | US9320741, JQ8
Type:
Small organic molecule
Emp. Form.:
C24H24ClN7OS
Mol. Mass.:
494.012
SMILES:
Cc1nnc2[C@H](CC(=O)NCCc3cnc[nH]3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:18|
Structure:
Search PDB for entries with ligand similarity: