Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 9
Ligand
BDBM413559
Substrate
n/a
Meas. Tech.
In Vitro Electrophysiological Assay
IC50
2000±n/a nM
Citation
 Delbeck, M; Hahn, M; Müller, T; Meier, H; Lustig, K; Mosig, J; Toschi, L; Albus, U; Gehring, D; Rosenstein, B Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same US Patent  US10414765 Publication Date 9/17/2019 
Target
Name:
Potassium channel subfamily K member 9
Synonyms:
Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2
Type:
PROTEIN
Mol. Mass.:
42276.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1457494
Residue:
374
Sequence:
MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYRQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHSFTDHQRLMKRRKSV
  
Inhibitor
Name:
BDBM413559
Synonyms:
US10414765, Example 43
Type:
Small organic molecule
Emp. Form.:
C28H24BrClF3N5O
Mol. Mass.:
618.875
SMILES:
FC(F)(F)c1cc(NC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)ccc1Cl
Structure:
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