Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM413880
Substrate
n/a
Meas. Tech.
Receptor Radioligand Assay
Ki
<100±n/a nM
Citation
 Virgili-Bernado, M; Alegret-Molina, C Substituted morpholine derivatives having activity against pain US Patent  US10421750 Publication Date 9/24/2019 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM413880
Synonyms:
5-(1-benzylpiperidin-4-yl)-7-(4- methoxybenzyl)-4-oxa-7- azaspiro[2.5]octane | US10421750, Example 12
Type:
Small organic molecule
Emp. Form.:
C26H34N2O2
Mol. Mass.:
406.5604
SMILES:
COc1ccc(CN2CC(OC3(CC3)C2)C2CCN(Cc3ccccc3)CC2)cc1
Structure:
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