Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM413932
Substrate
n/a
Meas. Tech.
Reporter Displacement Assay
Kd
>5000±n/a nM
Citation
 Jefson, MR; Lowe, III, JA; Dey, F; Bergmann, A; Schoop, A Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase US Patent  US10421756 Publication Date 9/24/2019 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM413932
Synonyms:
US10421756, Compound 116
Type:
Small organic molecule
Emp. Form.:
C21H23FN4O2
Mol. Mass.:
382.4313
SMILES:
CC(=O)N1C2CCC1CN(C2)C(=O)Nc1cc(ccc1N)-c1ccc(F)cc1 |TLB:1:3:5.6:9.10.8|
Structure:
Search PDB for entries with ligand similarity: