Reaction Details Report a problem with these data
Target
Interleukin-6
Ligand
BDBM331841
Substrate
n/a
Meas. Tech.
IL-6 Production Inhibitory Action Evaluation Test
IC50
13.0±n/a nM
Citation
 Kawashima, K; Yamazaki, Y; Takaoka, S; Shii, D; Oda, T; Matsuyama, T [4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or salt thereof US Patent  US10435379 Publication Date 10/8/2019 
Target
Name:
Interleukin-6
Synonyms:
B-cell stimulatory factor 2 | BSF-2 | CDF | CTL differentiation factor | Hybridoma growth factor | IFN-beta-2 | IFNB2 | IL-6 | IL6 | IL6_HUMAN | Interferon beta-2
Type:
n/a
Mol. Mass.:
23717.96
Organism:
Homo sapiens (Human)
Description:
P05231
Residue:
212
Sequence:
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
  
Inhibitor
Name:
BDBM331841
Synonyms:
(S)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphenyl]-8-(5-fluoro-2-methyl-phenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one | US10189796, Compound 5-2 | US10435379, Compound 5-2
Type:
Small organic molecule
Emp. Form.:
C30H32FN3O5
Mol. Mass.:
533.5906
SMILES:
COc1cc(OC[C@@H](O)CC#N)ccc1-c1ccc2NC(C)(C)C(=O)N(C)c2c1COc1cc(F)ccc1C
Structure:
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